No, not if you're running forced air induction with a drilled lid. Works a treat as the cooler air is more dense despite being sparse. The ram effect is maximised at altitude naturally, and use of HRC (high revving contraption) stuffers can also prevent hypoxia when really going for it...
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MC21SP Plaything
BMW F800GS Bumblebee
Triumph 9551 Daytona Big boys toy
FJ1100 Sporting relic
GTS1000 oddball